Abstract: The study investigated the impact of HIV/AIDS related stigma and discrimination among Pwani University Community. The research design used was a baseline survey. To ensure equal representation, simple random sampling was done of 196 participants from nursing students department and academic and non-academic technical staffs who were on session during the long vacation. The Tools used to collect data included questionnaires, Focus Group Discussions and interview schedules. Both qualitative and quantitative data analysis methods were employed. The study established that members living with HIV infection suffer isolation, rejection and forms of non-physical abuse. The Rights of students to educational activities were found to be infringed through isolation and peer formations during practical and various student activities. Quite a number of interviewees had at least experienced or observed cases of HIV/AIDS related stigma and discrimination in their interaction with others within the university community. Study recommended intervention strides at three levels; individual, community and organization but concluded that individual responsibility and positive perception was key in coping in a stigmatized environments to help build self esteem which may reduce discrimination mind set in individuals.