IJSRP, Volume 5, Issue 1, January 2015 Edition [ISSN 2250-3153]
Jayaram Mohan, Hena Firdaus, Upendra Nongthomba and S. R. Ramesh
LIM domain proteins are involved in diverse biological processes, such as, development and differentiation, by assisting in protein- protein interaction. Beadex, the LIM only protein in Drosophila, is coded by dLMO gene. Beadex has two tandemly repeated LIM domains. Beadex is normally expressed in the wing pouch of the third instar wing imaginal disc during patterning. Initial studies with Bx gain of function mutants showed that over-expressed Beadex can bind to Chip and thereby interfere with formation of a functional complex between Apterous and Chip during wing development. Beadex localizes in nucleus in early stages of muscle development. Present study is to understand the role of Beadex in muscle function. We show that Beadex is necessary for survival and proper functioning of the Indirect Flight Muscle in Drosophila.