Abstract: Antibacterial resistance to common antibiotic has increased overtime; there is thus the need to look for an alternative medicine to stem the trend. This study reported incidence of β-lactamase producing Klebsiella pneumonia from patients. The antibacterial activity of crude aqueous and ethanolic extract of Phyllanthus niruri was also investigated against some test bacteria. Antimicrobial activities were analyzed using agar diffusion method. Experiments were performed in triplicate and reported as mean ± standard error of mean and difference was analyzed using one way ANOVA at p≤0.05. Sixty five percent (65%) and 25% of urine and wound samples were positive to β-lactamase producing K. pneumonia respectively. The highest zone of inhibition (22.0mm) was observed in a concentration of 0.5g/mL from ethanolic extract against K. pneumonia. While the minimum inhibitory concentration (MIC) of aqueous and ethanolic extract of the plant was evidenced in 0.2g/mL and 0.1g/mL respectively. From the foregoing this study has shown that P. niruri extract have potential to be remedy for infectious disease caused by β-lactamase producing K. pneumonia.