Abstract: A total of 1200 pregnant women attending antenatal clinic in Hospitals in Okigwe Local Government Area, were screened for the presence of malaria infection and factors for pre-clampsia (proteinuria and high blood pressure) using Giemsa stain, dipsticks (Albustix) and sphygmomanometer. The prevalence of malaria infection, proteinuria and high blood pressure among pregnant women attending antenatal clinic in Okigwe Local Government Area (L.G.A) in relation to age group, malaria was highest among 17-21 years (26.1%), followed by the age group of 37-41 (20.6%) and least age group was >42 years (2.7%). The result also showed that the prevalence of malaria was highest at Divine Hospital (17.2%), followed by General Hospital Okigwe (13.9%), and the least was observed at Eve hospital (6.9%), was considered statistically significant. While proteinuria among the pregnant women revealed that the age group of 22-26 years had the highest prevalence rate of 7.5%, followed by 17-21 years (5.5%) and the least was >42 (1.3%). Proteinuria was more prevalent among pregnant women attending Okigwe General Hospital (5.7%), while the least was found at Divine maternity (3.0%). The prevalence of high blood pressure among pregnant women in relation to age group showed that, the age group of 37-41 years had the prevalence rate of 42.8%, followed by 22-26 years (13.9%) and the least prevalent was >42 years (1.3%). General Hospital Okigwe recorded the prevalence rate of 10.4%, and the least was Eve Hospital (5.1%), (p <0.05), age differed significantly in the study population. It is imperative to improve the quality of services in antenatal clinics so as to detect women who are at risk to malaria and complications such as pre-eclampsia.