Abstract: Pulmonary tuberculosis is a global problem requiring 6-month MDT-DOTS continuous treatment. This time based treatment along with the combination of VCO nutritional supplement and/or Catfish-extracted albumin has shown a significant benefit on improving immune response, accelerating the conversion of BTA sputum, increasing nutritional states and improving chest X-ray imaging in people with active pulmonary TB. This study aimed to compare the changes in pulmonary TB patients treated MDT-DOTS combined with supplemented VCO and/or albumin with that in the MDT-DOTS placebo group. The experimental study was designed by using two pre and post test groups with double blind randomized controlled trial. Eighty (80) participants met with study inclusion and were randomly distributed in the experimental groups. The study result has shown significant improvements in all observed variables among the experimental groups receiving the combination of MDT-DOTS with VCO and/or Catfish-extracted albumin. These are including accelerating the conversion of BTA sputum (VCO i.e. p<0.00; Catfish-extracted albumin i.e. p<0.04; and VCO + Catfish-extracted albumin i.e. p<0.00), increasing nutritional state (VCO i.e. p<0.03; Catfish-extracted albumin i.e. p<0.003; and VCO + Catfish-extracted albumin i.e. p<0.01) and improving chest X-ray imaging (VCO i.e. p<0.04; Catfish-extracted albumin i.e. p<0.003 and VCO + Catfish-extracted albumin i.e. p<0.001). MDT-DOTS treatment combined VCO nutritional supplement and/or Cat fish - extracted albumin capsules could accelerate the conversion of sputum smear, could improve nutritional status and improve chest X-ray imaging.