Abstract: Background and Purpose: Prostate Cancer Antigen 3 (PCA3) and Multi parametric Magnetic Resonance Imaging (mp-MRI) are promising tools for prostate cancer detection. As the most specific marker for prostate cancer, PCA3 had been studied and proved its use fullness in detecting prostate cancer, it is over expressed in prostate cancer. The capability of multi parametric acquisition in MRI improves detection rate. Molecular alteration happens prior to morphological change, both modalities utilize molecular changes as an early sign of prostate cancer. This research will study the correlation between PCA3 as molecular marker in blood with non contrast mp-MRI score also Apparent Diffusion Coefficient (ADC) value asmolecular imaging.