Abstract: Objective: This study examined the roles of self-esteem and social skills in perceived stress among female senior secondary school students in Iran. Method: Using cluster random sampling, 357 female students (ages 15–18) were recruited from District 1 of Karaj. Participants completed the Coopersmith Self-Esteem Inventory, the Matson Evaluation of Social Skills with Youngsters, and the 14-item Perceived Stress Scale. Pearson correlations and simultaneous multiple regression were conducted.