Abstract: Background of the study: Since Helicobacter pylori was first cultured by Warren and Marshall in 1983, much has been learned about its clinical aspects and its epidemiology. Knowledge of the epidemiology of this infection comes mainly from prevalence studies. In this research work, the prevalence of Helicobacter pylori infection was studied among patients with non-ulcer dyspepsia in the Out-Patients Department of four selected hospitals in Zaria, Kaduna State, to assess the risk factors associated with the infection.