Abstract: The study investigated the influence of motivation and job satisfaction on teachers’ intention to quit teaching in public senior high schools in Tamale Metropolis, Ghana. Data were collected using self-reported questionnaire from 203 teachers in selected schools in Tamale Metropolis. Cross-sectional survey design was used with questionnaire as the main data collection instrument using a multi-stage sampling procedure. Regression analysis and descriptive statistical analysis were employed in discussion of the data. The results revealed that job satisfaction made the most significant but negative contribution to intention to quit. Motivation made the least but significant contribution to intention to quit. It is recommended that training and development programmes as well as offering of more extrinsic motivation variables by all stakeholders in the education sector is required to retain more teachers in public schools.