Abstract: Toxic metals are widely found in our environment and are mainly caused by the use of the pesticides, industrial activities and mining operations. One of them is arsenic that accumulates in the liver tissue to toxic levels and cause changes in the activities of several liver enzymes and cellular damage. Enzymes like aspartate aminotransferase and alanine aminotransferase are found predominantly in liver tissue and cellular damage as a result of arsenic exposure releases these enzymes into the blood stream and the plasma levels of these enzymes indicate hepatotoxicity. The objective of this project is to review the several research works on the effect of arsenic on liver tissue of fishes and rats at different time of exposure.The resources used for this review were obtained from published work in several peer review journals. ALT activity has shown an increase of 6.03%, 13.61% and 27.75% at different doses of exposure and the AST has shown also an increase of 9.04%, 16.32% and 38.08% at different doses in fishes. The GDH activity has shows an increased level of 9.61%, 23.72% and 34.62% at different doses when compared to control groups of fishes. Varied degrees of changes (mild to severe) were also observed in groups of fishes and mice exposed to different doses of arsenic and results in necrosis of the hepatocytes, central vein and sinusoidal spaces expansion due to shrinkage. Other result has shown that fish exposed to different concentrations of NaAsO2 have shown varied degrees of changes i.e. death in high concentration; however, as the concentrations decreased, the survival period increased gradually. The FTIR spectra revealed also significant differences in absorbance intensities in the amide bands between control and arsenic intoxicated liver tissues. Among the results reported most of which have shown increment and some of them have shown decrement when compared to the control groups up on the exposure of different concentration of arsenic i.e. (28.30 mg/L