Abstract: Anabolic-androgenic steroids (AAS) are the synthetic derivatives of testosterone which are widely accepted as performance enhancers and illicitly self-administered to increase muscle mass and physical endurance. The use of anabolic steroids by sportsmen and teenagers has increased to such extents thereby raising questions about their hepatotoxicity. The present study elucidates the adverse effects of AAS when administered at supraphysiological doses. Its focus is on the effects of massive doses of nandrolone decanoate, the most commonly abused AAS on the levels of the two important enzymatic liver biomarkers, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in albino mice. Tissue samples (liver tissue) were collected from normal control and nandrolone decanoate treated (2.5mg twice a week, administered intramuscularly for 13 weeks) albino mice and AST/ ALT levels of liver tissue were measured by following the method of Reitman and Frankel (1957).