Abstract: Background: Premature Rupture of Membranes (PROM) increases maternal and neonatal morbidity through inflammatory mechanisms. Hematological markers such as leukocyte count and neutrophil-to-lymphocyte ratio (NLR) may serve as cost-effective inflammatory indicators. Objective: To compare leukocyte levels and NLR values between pregnancies with PROM and normal pregnancies. Methodology: This cross-sectional study included 72 subjects (36 PROM, 36 normal pregnancies) at Adam Malik General Hospital and affiliated centers. Complete blood count data were analyzed using appropriate statistical tests (p<0.05). Results: Leukocyte levels were significantly higher in the PROM group versus normal pregnancy (14.33±4.59 vs 11.02±2.25 thousand/µL; p=0.010). NLR values were markedly elevated in term PROM (12.16±6.86) and preterm PROM (11.08±7.04) compared to normal pregnancy (median 4; p<0.001). Post-hoc analysis confirmed significant differences between PROM/PPROM versus normal groups. Conclusions: NLR demonstrates potential as a simple, accessible biomarker for detecting inflammatory conditions in PROM, supporting early clinical assessment in resource-limited settings.