Abstract: Coronavirus disease (COVID-19) caused by SARS‐CoV‐2 is a highly infectious disease that primarily affects the respiratory system but is characterised my multisystem inolvement of other systems as well. The various reported extrapulmonary and unusual manifestations are neurological complications, hepatic and gastrointestinal complications, renal dysfunction, myocardial injury etc; some of which have been described in this article to shed light on the wide range of clinical spectrum displayed by COVID-19 disease. It has been found that both adaptive and innate immunity is activated in this disease that results in a cascade of inflammatory responses that plays a major role in the multisystem complications caused by the disease. The article also lists the possible mechanisms by which the virus damages various other organs for a deep understanding of the disease process for physician guidance.