Abstract: In this research paper the main aim is formulation and development of Anti-fungal nail lacquer which is used in treatment of onychomycosis Anti-fungal nail lacquer which is used in treatment of Onychomycosis skin fungal disorder was focus on the disease causes and treatment by nail lacquer, onychomycosis causes by the pathogens include dermatophytes, candida, and non-dermatophytes. Improvement clinical efficacy and also proper the patients compliance. Nail Lacquer preparation by simple mixing non-volatile, gloss, smoothness to flow, drug diffusion studies drug content estimation, Nail lacquer is used on fingernails, toenails of the human beings. Which is protect the nail but, nail plate but most of significant in maximize the beauty, gloss, impart colour. Nail lacquer is mostly applicable for those drug which have poor bioavailability in oral formulation this techniques is used in maximize the topical bioavailability of drug across the nail.