Abstract: Recently, the quality of healthcare is a significant concern worldwide. Clinical laboratories are an essential part of healthcare services where more than 65% of medical cases are diagnosed by laboratory tests. Therefore, clinical laboratory results are playing a significant role in diagnosis, treatment and decision making. Excellent practice of quality management is an emerging issue to ensure quality control, reliable and accurate test results. The modern quality tools such as Lean and Six-sigma offer realistic and sustain approaches to increase efficiency, reduce cost, minimis errors, remove waste from working process in clinical laboratories.