Abstract: Background: We have ample of evidence that progression of renal failure can be slowed down but we still need more definite information whether established renal failure can be reversed. Retarding the progression of renal failure is one of the most important task for the nephrologists as it not only improves the quality of life of the patient but also delays the development of end stage renal disease, This also forestalls the considerable financial burden of dialysis, transplantation and immunosuppressive drugs. This pilot clinical study was planned to explore the therapeutic potential of salicinol in retardation of chronic kidney disease progression and anti-atherosclerotic property by looking for if reduction in CIMT is possible.