Abstract: Insects are among the pests that cause damage to crops. They attack the underground and above-ground parts of the plant, thus reducing its yield. The aim of our study was to investigate insect pests of Solo papaya flowers and fruits and diseases in an experimental plot in the locality of Meyomessala in Southern Cameroon. After three months of collecting pests and papaya fruits, the samples were identified by the symptom observation method on the fruits for diseases and by electron microscope observation for insects. The results reveal 17 insect species in our experimental plot.