Abstract: This study examines the effect of bank specific factors of profitability in Sri Lankan domestic commercial banks.This study conducted with a complete panel data and utilized the sample frame annual reports of the domestic commercial banks in Sri Lanka. A regression analysis is built on a strongly balanced panel data set including 60 observations of 12 Sri Lankan domestic commercial banks over the period 2011-2015.Bank size, Capital, Deposits, and Liquidity have been identified as independent variables and Profitability as the dependent variable.