Abstract: The liver exposed to 96-hour LC 50 concentration of cadmium chloride was studied in a freshwater murrel Channa striatus. The liver is very important organs in fish to achieve the process of detoxification and biotransformation, which is considered the most suitable indicators of water pollution levels. Changes of liver morphology and histology of Channa striatus due to sublethal concentration of cadmium chloride (6.9 ppm) heavy metals. After the exposure of cadmium chloride, the histopathological alterations observed in the liver tissue such hypertrophy of hepatocytes, nuclear hypertrophy, necrosis, blood congestion, vacuolation, cellular degeneration, damage of nuclei, bile stagnation and congestion in the blood sinusoids.