Abstract: Malaria is a parasitic disease caused by plasmodium parasite. This study was conducted to compare malaria vector density and malaria infection in Yola South Local government area of Adamawa State, Nigeria. The result of this study revealed that there was positive correlation between malaria vector density and malaria infection based on sites of location (R=0.007) and based on month (R=0.009). Malaria vector density was observed lowest in Upper Benue Quarters (9.52%) and in the same way the infection was observed lowest (6.72%) in the same site. Relationship based on month revealed that malaria vector density was observed highest in the month of August (40.48%) and in the same way malaria infection was observed highest (33.20%) in the same month. Also, malaria vector density was observed lowest in the month of September (20.83%) and in the same way the infection was observed lowest (19.70%) in the same month. The result of this study revealed that most of the malaria vectors sampled were either blood fed (28.57%); gravid (25.59%) or half gravid (27.38%).This implies high contact between the malaria vectors and human or other animal host. Control of malaria vectors is necessary to reduce the rate of infection.