Abstract: A One group pre-test post-test experimental study to assess the effectiveness of planned teaching program on knowledge of staff nurses regarding prevention of urinary tract infection among patients with indwelling catheter. The sample consisting of 90 staff nurses was selected by using simple random sampling. The tool comprised of structured self-administered questionnaire. The pretest was conducted and the planned teaching program was administered. The post test was conducted after one week. The data obtained were analyzed by using differential and inferential statistics.The mean score of post-test knowledge 21.53 (71.76%) was apparently higher than the mean score of pre-test knowledge 13.51 (45.03%), suggesting that the planned teaching programme was effective in increasing the knowledge of the staff nurses regarding prevention of urinary tract infection among patients with indwelling catheter. The mean difference 8.02 between pre-test and post-test knowledge score of the staff nurses was found to be significant.