Abstract: Aims and Objective- Present study was undertaken to see and compare the effect of solifenacine alone and solifenacine with duloxetine therapy in patients with overactive bladder. Material Methods:- The study was done on the patients with overactive bladder. The patients were diagnosed clinically by the physician and urologists. Before enrolling in the study each patient was asked to give a written consent. The outcome measures were evaluated in form of reducing the frequency, urgency and other clinical symptoms. Simultaneously we also measured the quality of life of the patients using accepted scale. Results and Conclusion:- Present study showed that addition of duloxetine with solifenasin has definitely produced better clinical improvement in patients as well as the quality of life was also imporved. Though minor side effects increased by this addition but overall quality of life was better in patients on combination therapy as compared to the single solifenasin treatment.