Abstract: Background: Breast cancer is the most common cancer found in women with approximately 23% cases of all cancer. It has been known that signaling through IGF-1R is involved in growth of many cancer especially breast cancer, for example by affecting cell proliferation, survival, invasion, and metastasis. One of the receptors in IGF pathway is IGF-1R. The research of IGF-1R expression and clinicopathological features in breast cancer patients is still controversial.