Abstract: This study was conducted to determine the effect of tannery effluent on seed germination of six different vegetable crops seeds under laboratory condition. The major objective of this research work was to make a comprehensive study on the status of vegetable seeds germination using different effluent treatments located in East Shoa, Ethiopia. The treatments were made by mixing measured amount of tannery effluent in distilled water i.e. 0, 25, 50, 75 and 100% concentrations on seed germination of six vegetable crops seeds, namely: onion (Allium cepa L.), carrot (Daucus carota L.), beet root (Beta vulgaris L.), Swiss chard (Beta vulgaris L.), tomato (Lycopersicum esculentum L.) and cabbage (Brassica oleracea L.). The seed germination experiment was carried out in Completely Randomized Design (CRD) with five effluent concentrations (treatments), each replicated three times. All vegetable crops seeds were grown in different effluent concentrations and the effects of different concentrations of effluents were compared to that of distilled water (control). Parameters considered to study the effect of effluents were percentage germination, shoot length (cm), root length (cm), seedling length (cm), fresh weight per seedling (mg), dry weight per seedling (mg) and relative toxicity (%). The results indicated that, application of effluent did not show any inhibitory effect on seed germination and other morphological parameters at low concentration except in onion, carrot and tomato, which were found susceptible with 75 and 100% effluent mixtures but, Swiss chard, beet root and cabbage were found resistant to all effluent concentrations mixtures. Based on the tolerance to tannery effluent, the vegetable crop seeds studied are arranged in the following order: Swiss chard > cabbage > beet root > tomato > carrot > onion. With the increase in effluent concentration, all plant parameters decreased accordingly. Different physicochemical parameters of water such as:- pH, temperature,