Abstract: The efficacy of hyro-ethanolic leaf extract of Fleurya aestuans on lead acetate-induced hepatotoxicity in 55 Wistar rats was investigated in this study. Animals weighing between 142.0 and 167.6 grams were split into two groups. A total of four groups make up Phase one. Groups 1 served as control group. Fleurya aestuans leaf extract was given at 50, 75, and 200 mg/kg to Groups 2, 3, and 4.