Abstract: Among vector born diseases, malaria is a wide spread disease and causing highest morbidity and mortality rates over all continents. According to WHO in 2016, about 216 million people were infected and 4,45,000 deaths were reported in the world. 90% of the malaria cases reported in Africa only. India’s physiographic, climatic and thick drainage system are favorable for the growth and distribution of malaria disease. Further India is having large population i.e human host with high density is also favorable condition for growth distribution of malaria disease. Malaria is endemic to Andhra Pradesh for over several decades. Further, there are no proper vector-control strategies that have led to a significant increase in the disease burden and are inadequate to prevent. In this context Andhra Pradesh is taken for the present study. Year wise data on Malaria Cases was collected for the 13 districts of Andhra Pradesh (2010- 2019) to investigate Malaria outbreaks. Further, the study will find out high risk malaria Districts in Andhra Pradesh.