Abstract: The impact of temperature and relative humidity on sex differences among schizophrenia patients at Neuropsychiatric Hospital, Akure, and Ondo State, Nigeria was examined in this paper. Two independent variables (temperature and relative humidity) and one dependent variable (number of schizophrenia patients that visited the hospital from (2010-2017) data were collected. The population of study were 13,834 (in-patients and out-patients) for the period of eight years; that comprised 7,290 (52.70%) female and 6,544 (47.30%) male schizophrenia patients. The collected data were analyzed with the use of single regression and multivariate regression analyses.