Abstract: BACKGROUND: Coronary artery disease (CAD) is the leading cause of death in India and worldwide. CAD is most commonly due to atherosclerosis of the coronary arteries. Empirical evidence suggests that inflammation plays a critical role in all stages of atherosclerosis. Of the potential risk factors, high sensitivity C - reactive protein (Hs -CRP), is one of the downstream vascular inflammatory marker and most promising. It is considered to be the most robust tool with test characteristics desirable and subservient for clinical use.