Abstract: The study was conducted in twelve clinical cases of horses undergoing diagnostic and surgical procedures warranting general anaesthesia. The cases were randomly divided into two groups: group I and group II, each consisting of six horses. Pre-anaesthetic medication done with Xylazine hydrochloride @ 0.5mg/kg and Acepromazine maleate @0.03 mg/kg body weight in both the groups. Ketamine @ 2.20 mg/ kg body weight and 0.05mg/kg/min was used as induction and maintenance agent in group I and Propofol @ 2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance agent in group II. The total serum protein showed no significant reduction after sedation, after induction, during maintenance and after recovery in both the groups. There was no significant difference in the neutrophil, lymphocyte, eosinophil, and monocyte counts in both the groups. The magnitude of blood glucose level was lower in group II compared to that of group I. Group I exhibited an increase in plasma cortisol level, when compared to that of group II.