Abstract: West Africa region has seized to be the traditional warehouse and transit routes for illicit drugs from the Andeans stable to America and European drug markets. The influence of the culture of hard drugs has taken a more than a foothold in the region as production, manufacture/processing has passed the experimental stage and consumption is highly potent. The fear is that, the region may turn into theatre of conflict, crimes, violence and lawlessness which is even more favourable condition for the trade. Most scholars and extant literatures has focused on poor economies weak rule of law and corruption as the endogenous causative factors that has made the region vulnerability and flourishing of illicit drug trade, but importantly, deliberately overlooked the exogenous underpinnings such as high demand for drugs, and the vicious, desperate and determined traffickers to feed on this demand.