Abstract: This study aimed to investigate the risk management of Cadmium (Cd) for people who consumed Leiognathus sp., Portunus pelagicus, Anadara sp. and Penaeus sp., from Tallo River in Tallo Village of Makassar City, Indonesia. Observational study was used by appliying environmental health risk assessment approach. The Cadmium levels in Leiognathus sp., Portunus pelagicus, Anadara sp. and Penaeus sp, were measured with the Atomic Absorption Spectrometry Perkin type 210 Germany. Ninety six (96) respondent’s body weight, consumption rate and exposure time duration were analyzed quantitatively to calculate the risk quotient (RQ). Result implied that the risk quotient value due to Leiognathus sp. consumption was 0.1655 (for a level of 0.00048 mg/gram).