Abstract: Methanolic extract (Me) of vanilla pods and commercial vanilla, hexane (He), benzene (Be), ethyl acetate (Ea), n-butanol (nBu) and aqueous (Aq) fractions of methanolic extract of vanilla pods and commercial vanilla essence were analyzed for radical scavenging activities viz. DPPH radical, hydroxyl radical, superoxide radical and nitric oxide radical scavenging activities to screen the best fraction of the methanolic extract (Me) of the samples that posses the highest free radical scavenging activity. All the fractions and methanolic extract of both the samples have individualized and concentration dependent activities.