Abstract: Background: Dengue Fever is the most geographically widespread arthropod-borne disease. It can present a variety of clinical spectra varying from asymptomatic illness to dengue shock syndrome. Case Presentation: 42-year-old female patient who has presented with a three-day history of fever and subsequently developed dengue hemorrhagic fever with multi-organ failure. Despite intensive care management, the patient died three days after admission to a tertiary care hospital. Conclusion: Early recognition of dengue hemorrhagic fever and appropriate management during the critical phase are crucial.