Abstract: In day to day practice, Prosthodontists and General Dentists frequently come across patients who have extreme oral sensitivity by which they are unable to tolerate any foreign material in the oral cavity. Patients with such sensitivity often complaint of nausea, gagging or vomiting during the dental procedures which creates a difficult situation to manage. The objective of this paper is underline and understand the neurophysiology of gag reflex and enable an operator to manage this situational emergency.