Abstract: The antioxidant effect of aqueous extracts of Daucus carota root and Moringa oleifera leaf were investigated in anti-tubercular drugs (isoniazid, INH and rifampicin, RMP) induced oxidative stress.The test control rats were administered with INH (27mg/kg) and RMP (54mg/kg) for 4 weeks to induce oxidative stress. Rats were pretreated with doses of 100mg/kg and 200mg/kg of aqueous extracts of Daucus carota and Moringa oleifera respectively for 4 weeks then INH and RMP were administered for another 4 weeks. Rats were also co-administered with 100mg/kg and 200mg/kg of the extracts plus INH and RMP for 4 weeks. The effect of the extracts on oxidative stress was determined by monitoring the serum malondialdehyde (MDA) concentration. Pretreatment and co-administration of Daucus carota and Moringa oleifera aqueous extracts significantly (P<0.05) reduced serum MDA levels compared with the test control. The co-administration of the extracts with the anti-tubercular drugs had a more profound effect in reducing serum MDA concentration compared with pretreatment with the aqueous extracts of D. carota root and M. oleifera leaf. Moringa oleifera leaves and Daucus carota rootsmay afford anti-oxidant effect in anti-tubercular drugs- induced oxidative stress.