Abstract: S-triazine and thiocarbamide group containing drug create their own identity in the drug, pharmaceutical and medicinal sciences. Refractrometric measurements of recently synthesized drugs viz. 1-(4-hydroxy-6-methyl)-S-triazino-3-phenylthiocarbamide (L1) is carried out at various percentage composition of solvent and at different temperatures to investigate effects of structure, groups on S-triazino thiocarbamides. The data and the results obtained during this investigation gave detail information regarding drug absorption, transmissions activity and effect of these drugs. This study explores the potency of newly synthesized drugs, stability of drug and also to renovate and modify the traditional drugs which are used by medicinal practioners. Taking all these things in to consideration this research work was carried out.