Abstract: A new ketone Isonitroso phenyl 2 propanone (HINP2P) has been synthesized by the reaction of Benzyl magnesium chloride with cadmium chloride and acetyl chloride. On subsequent treatment of Phenyl 2 propanone with n- amyl nitrite gives Isonitroso Phenyl 2 Propanone. The structure of these compounds has been confirmed by physiochemical and spectral data. A preliminary screening of these compounds for biological activity against microorganisms has indicated that they are selective growth inhibitors.