Abstract: The COVID-19 pandemic destabilized governments and impacted negatively on national, regional, and local economies. Decision makers were faced with sudden challenges that required radical decisions that impacts directly on people lives. This article presents concepts of decision making and several behavioral decision theories to attempt to explain the decision-making environment and the macroeconomic choices by the Nigerian Government. Normative and descriptive behavioral decision theories (Takemura, 2014) were briefly explained. The paper observed that Nigeria’s response to COVID-19 is very slow and the decision to relaxing the lockdown might have been influenced by asymmetric learning from the prior and current economic and social challenges faced by the country and might not be due to empirical evidence and actual medical standard’s needs.