Abstract: The aim of this study is to examine the effect of information quality on decision making effectiveness in Palestinian banking sector. Previously it shows that there are limited studies that explored the link between these variables in Palestine. In this study, decision effectiveness was measured in terms of decision quality. The data in this study was collected from bank managers in Palestine using survey instrument. The collected data wereanalyzed using PLS software and the findings indicated that information quality plays an important role in decision making effectiveness. Particularly, this study found that accuracy of information has significant effect on decision effectiveness. Moreover, relevance of information has significant positive effect on decision effectiveness. Centralization of the organizational structure has positive moderation effect on the relationship between information quality dimensions and decision making effectiveness.