Abstract: In the present study an attempt is made to investigate sex related difference in handedness among adults. It was hypothesized that there will be a difference in the performance of males and females on measure of handedness. 704 males and 840 females were given a group test of handedness. The result indicates that females tended to score significantly high on performance test of handedness than males. The sex difference was statistically significant for right-handers but not for left-handers.