Abstract: Kidney diseases is ranked – 3rd amongst life threatening disease in India, after cancer and heart disease. About 200,000 persons go into terminal kidney failure every year. Erythropoietin is the primary regulator of red blood cell formation in the bone marrow, which are mostly produced by the renal epithelial cells. This study was carried out to observe the hematological changes like RBC count, Hb concentration, hematocrit, platelet count and TLC in patients suffering from chronic renal failure.