Abstract: A performance analysis on a vapour compression refrigeration system with various eco-friendly refrigerants of HFC152a, HFC32, HC290, HC1270, HC600a and RE170 were done and their results were compared with R134a as possible alternative replacement. The results showed that the alternative refrigerants investigated in the analysis RE170, R152a and R600a have a slightly higher performance coefficient (COP) than R134a for the condensation temperature of 50⁰C and evaporating temperatures ranging between -30⁰C and 10⁰C.Refrigerant RE170 instead of R134a was found to be a replacement refrigerant among other alternatives. The effects of the main parameters of performance analysis such as refrigerant type, degree of sub cooling and super heating on the refrigerating effect, coefficient of performance and volumetric refrigeration capacity were also investigated for various evaporating temperatures.