International Journal of Scientific and Research Publications

IJSRP, Volume 11, Issue 8, August 2021 Edition [ISSN 2250-3153]


Correlation of Glucose Transporter-1 (GLUT-1) Immunohistochemical Expression on Benign, Borderline, and Malignant Phyllodes Tumors
      Riski Hidayat, Delyuzar, M. Nadjib Dahlan Lubis
Abstract: Background: Phyllodes tumor (PT) is a rare fibroepithelial neoplasm, wherein constitutes 0.3-1% of all breast tumors. According to the WHO classification, PTs are divided into benign, borderline, and malignant. Malignant transformation is often accompanied by significant metabolic changes. In 1924, biochemist Otto Warburg and his colleagues discovered that cancer cells take up large amounts of glucose and metabolize it via glycolysis to lactic acid, then is called the “Warburg effect”. High activity of glycolysis is associated with high uptake of glucose in cells. Glucose in the metabolic process requires a specific protein carrier in order to pass through the plasma membrane of cells. This process is regulated by the glucose transporter (GLUT). Abnormal expression of GLUT-1 is associated with aggressiveness of tumor growth and poor prognosis.

Reference this Research Paper (copy & paste below code):

Riski Hidayat, Delyuzar, M. Nadjib Dahlan Lubis (2021); Correlation of Glucose Transporter-1 (GLUT-1) Immunohistochemical Expression on Benign, Borderline, and Malignant Phyllodes Tumors; International Journal of Scientific and Research Publications (IJSRP) 11(8) (ISSN: 2250-3153), DOI: http://dx.doi.org/10.29322/IJSRP.11.08.2021.p11641
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