Abstract: Neonatal mortality is one of the determinants of children’s health and well-being. SDGs are targeting to reduce neonatal mortality at least up to 12/ 1000 live births. The neonatal mortality rate in the Hulu Sungai Selatan Regency in 2018 is the highest in the South Kalimantan Province of 18/ 1000 live births. This research aims to analyze the relationship between maternal age, parity, gestational age, pregnancy complications, childbirth complications, infant birth weight, asphyxia, congenital abnormalities, and birth attendants with neonatal mortality in the Hulu Sungai Selatan Regency in 2018. This study was an observational analytic study with a case-control design conducted in Hulu Sungai Selatan Regency. The sample of the study was 41 cases and 43 controls.