Abstract: Phyllanthus amarus, Alstonia boonei, Nauclea latifolia are plants which are present abundantly in Nigeria and other tropical countries. The success of chemotherapy against the challenge posed by the dynamic emergence of resistant strains lies in the continuous search for new potent drugs. Plant-derived antimicrobials have a long history of providing the much needed novel therapeutics and lead compounds. This study investigated the antimicrobial activity of methanol and n-hexane extracts of the leaves of three ethnomedicinal plants; Alstonia boonei, Phyllanthus amarus, and Nauclea latifolia against a panel of clinical significant microorganisms viz Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Candida albicum and Candida tropicalis.