Abstract: Background: Tumor infiltrating lymphocytes (TILs) have been important prognostic factor for many malignancies, including cutaneous squamous cell carcinoma (cSCC). TILs are composed of many subsets, categorized into T-cells and B-cells. The tumor immune responses of B-cells are poorly investigated and ignored for years. The role of B-cells in tumor immunology is still controversial due to the antitumorigenic effect and also the ability to increase the tumor progression.