Abstract: A cross- sectional quantitative study carried out in Kigali within a one year period (July 2011 to June 2012). It evaluated knowledge, attitude and practices towards TB infection among TB diagnosed patients. Sample of 411 TB patients was randomly and proportionately drawn for the study. The validated and translated questionnaires comprised participants’ socio-demographic characteristics, 11 items Knowledge questions, 13 item attitudes questions and 10 practices questions. Trained community health workers at health center, interviewed participants face to face during their routine daily treatment at the health Centre. Data from the field were sorted out, arranged and analysis with SPSS based on analysis plan.