International Journal of Scientific and Research Publications

IJSRP, Volume 4, Issue 8, August 2014 Edition [ISSN 2250-3153]


Vitamin D receptor gene polymorphisms and vitamin D status and susceptibility to type 2 diabetes mellitus in Moroccans patients
      Errouagui Abdeltif1, Houda Benrahma1, Hicham Charoute1 , Hamid Barakat1 , Mostafa kandil, Hassan Rouba
Abstract: Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to Type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the association between VDR gene polymorphisms and T2DM in Moroccans patients. Materials and Methods. 176 clinically diagnosed T2DM patients and 177 healthy controls from the Moroccans population were recruited. BsmI(rs1544410), FokI(rs10735810) and ApaI (rs7975232) single nucleotide polymorphisms (SNPS) of the VDR gene were determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). A Vitamin D level was determined using ELISA. Results. The prevalence of Vitamin D deficiency and insufficiency is significantly higher in patients with T2DM than in the control subjects.

Reference this Research Paper (copy & paste below code):

Errouagui Abdeltif1, Houda Benrahma1, Hicham Charoute1 , Hamid Barakat1 , Mostafa kandil, Hassan Rouba (2018); Vitamin D receptor gene polymorphisms and vitamin D status and susceptibility to type 2 diabetes mellitus in Moroccans patients ; Int J Sci Res Publ 4(8) (ISSN: 2250-3153). http://www.ijsrp.org/research-paper-0814.php?rp=P322989
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