Abstract: Background: Squamous cell carcinoma (SCC) is the most common malignancy of the penis with mostly lymphogenous metastases to the inguinal lymph nodes. Inguinal lymph node metastasis is the most important factor for predicting the survival of penile SCC patients and determining treatment options. The biological phenomenon of tumor budding has been described in various tumors where it has independent predictive and prognostic relevance. The phenomenon of tumor budding in penile SCC is still unclear.