Abstract: The development of antimicrobial resistance by members of the genus Salmonella has a significant impact on the antibiotic treatment of Salmonella infections. This study investigated the plasmid-mediated quinolone resistance (PMQR) genes associated with Ciprofloxacin resistance in Salmonella typhimurium (S. typhimurium) from cattle faeces from abattoir in Keffi, Nasarawa State, Nigeria.